Electrophoretic Theory of Cancer

I have been following the progress of the clinical trials of sodium dichloroacetate as a potential treatment for cancer through the public media. I am thankful that Health Canada would take the initiative to fund this research and would like to offer a contribution of my own.

Although I have no medical training, nor received more than a basic education in organic chemistry, I have been performing my own independent research and have come up with a hypothesis regarding DCA's effect on restoring mitochondrial function to cancerous cells. I also have a suggestion for a possible natural compound that I believe may serve the same function while minimizing the toxic side effects in sufficiently small doses.

The Electrokinetic Properties of DCA

My hypothesis is based around the electrokinetic properties of the dichloroacetate ion and how it might affect the overall chemical concentration gradient within cells. In the attached diagram, I have provided an atomic mass ratio comparison of the acetate and dichloroacetate ions, as well outlined the possible spin states that this arrangement of atoms could produce.

As you can see, in the chlorinated acetate the center of mass for rotation has moved from being centered towards the carboxyl group to the halogenated carbon. This new axis of rotation would give carboxyl group a functional character not present in the normal acetate ion, thereby magnifying its electrokinetic properties. I hypothesize that within cells this ion then plays a role in altering chemical gradients as described by electrophoretic theory, restoring a key balance which reactivates mitochondrial function, leading to the eventual apoptosis of the cancerous cell.

Diodoacetate Ion as a natural analog for DCA

While researching this possibility it occurred to me that a similar ion, diodoacetate (DIA), may serve the same functional role within cells while producing diminished toxic effects. The above image compares the atomic mass ratios of dichloroacetate with diodoacetate.

As you can see, this atomic mass ratio of the halogenated carbon to the carboxyl group is much larger, which should magnify the electrokinetic influence of the carboxyl group even further. The only mention of this ion I've discovered describes its use in the separation of proteins in the presence of this particular compound. (http://www.jbc.org/cgi/reprint/268/26/19422.pdf - Page 2, ) Although I have not been able to discover any mention of this ion being isolated in nature, my second hypothesis is in regards to this iodine-based acetate ion existing in ocean plant life and already being consumed as a regular dietary supplement in the Asian world.

Natural Sources for DIA

Brown algae like kelp and seaweed are natural concentrators of iodine from sea water. They are unique among the algae in their production of differentiated tissues. Also, certain members of the brown algae family can grow up to a half a meter a day, up to a length of 80 meters. This high growth rate would seem to require a means for combating cancer-induced metastasizing within the organism's tissues. Unlike within the human body, in which cancerous cells migrate into other tissues and organs once cellular cohesion has diminished, in seaweed or kelp metastasizing of tissues could lead to the total dissolution of the organism as its cells migrate out into the surrounding water. I propose that the brown algae evolved to accumulate iodine, the heaviest of the organic elements, to produce this acetate analog and maintain a proper electrokinetic balance and chemical gradient within their cells.

Kelp and seaweed have already been noted as possibly possessing anti-cancer properties, although the active biological component has never been identified. Cancer rates amongst countries that consume members of the brown algae family, such as China or Japan, are the lowest in the world. Yet, they also tend to have the highest rates of gastrointestinal cancers. This electrokinetic theory of cancerous cells suggests that cells exposed to a unusually high level of these ions would leave their internal chemical balanced shifted into an equally unhealthy state, leaving the cells and tissues regularly exposed to these higher doses at an equal risk for developing cancer.

Update:

I found a lab that can synthesize this stuff for $6800 for a 200 gram sample. Some people have reported success with DCA doses in range 10 milligrams per day, so for $6800 you'd get about 20,000 daily doses of DIA. Hell of a lot cheaper than chemo, which is why pharmaceutical companies aren't interested in researching DCA in the first place. At $11,889 for 8 weeks of FOLFOX treatment (When will the US flinch at Cancer Drug Prices?), there's obviously no money in researching possible cancer cures, just treatments.

However, because the compound includes iodine, this is probably too large of a daily intake. Recommended iodine intake is in the range of micrograms per day, but the toxicity level is around 2-3 grams, so it's hard to say. If the daily recommended intake is in the range of micrograms, you'd get 20,000,000 ten microgram doses out of a 200 gram sample. For $6800, you could provide enough of this dietary supplement to last one person 54,794 years. Or 547 people who live 100 years a piece.

And of course, this also may be available for free in fresh seaweed.

College, Video Tapes and Phononic Computers

Been a while since I've written, but I've been tied up with college and the variety of odd jobs I do to try to keep money in my pocket.

College is going well. Despite this being my third time attending post-secondary (I've got two years of a Physics major as well as Comp Sci, Business and Philosophy from previous years) I feel pretty confident in my ability to get that damnable piece of paper that might help me get a better job.

Aside from that, I've also been working on a project proposal for the Labrador Institute. They've got an archive of old video tapes that they'd like converted into DVDs, so I've been conducting a lot of research into how to get the best quality captures from each tape. Considering they'll want several hundred tapes turned into 4 DVD sets each, it could take quite some time, but should be worth it in the end. Some of these tapes are the last remaining copies, so I'd like to do the best job possible.



Finally, last week a group of physicists in Singapore validated another idea I'd been toying with since I started researching peltier elements almost 3 years ago. Although I was thinking more along the lines of a 'thermal processing engine' that could also provide quantum elements, they've labelled it a Phononic Computer, which basically amounts to the same thing: a computer that uses heat to process information rather than electricity. However, they aren't looking for quantum elements, just standard logic gates with binary output, so I've still got my own little contribution to make somewhere along the line. Might have to go ahead and complete my electronics engineering program before I'll be taken seriously. You'd think it wouldn't be that difficult considering I called that solar cell advancement a year and a half before it was ever published, but thats life I guess.

Back to School

I've had a few interesting weeks.

I worked crushing uranium ore samples for three days. Just long enough for me to get to gamma radiation in my reading and have a chance to play with their old-school geiger counter, but not before I'd already crushed and milled over a hundred samples. And it's not easy work. The cotton masks they give you cut off a hefty percentage of your oxygen supply while you're working, leaving you constantly gasping for air when you've got two machines in full swing. I still can't breathe properly and it's been almost two weeks now. The machine that produced the most radioactive dust during the whole process was appropriately named "The Terminator."

So I went into work on the fourth day, told them it wasn't working out, then immediately went down to the college and registered for their engineering program. I've got a ton of ideas floating around in my head for different design geometries for traditional solid state devices, as well as some brand new concepts that I'll probably spend the next three years researching. Real exciting stuff... to me at least.

Either way, I've finished my first two days and am avidly reading over the material thats been supplied. I hope to stay ahead of the class, as I seriously slacked off during my 'searching' period at University. I think it's safe to say that I'm in more of a 'seek-and-destroy' mentality now.

Screw Patents

Upon further thought, I've decided that most of the ideas surrounding intellectual property are garbage anyways and patents will require too much time and energy to write when the system electrical systems that will be required are possibly still decades away.

Instead, I'm taking all this bullshit and chucking it out the window. There's no point in one person stressing himself out so much over things that he can not control.

I'm thinking I'll probably put together a quick YouTube short featuring some info about the Weedshare alternative... simply because it was a real step forwards in digital distribution that's currently being moved against by most corporate interests. DRM is now being phased out in favor of watermarking, which means that instead of restricting access to media, it'll just be easier to figure out who you stole it from. Although MS will definitely still be seeking financial gain through their two patents which cover the Weedshare-style distribution and Zune-a-like media marketplace.

I'm going to coin a new term for this blog:

D. R. E. - Digital Rights Enforcement

While the RIAA is (apparently) acting to reduce piracy and ensure that artists benefit from their work (doubtful), there's no real agency acting to preserve and protect the rights of the consumer.

A digital distribution system that allows consumers to act as middle marketers for their favorite bands is a definite step forwards. However, if the companies responsible for maintaining the database of purchases and ownership cannot be trusted to stay float indefinitely, they do not actually create a form of permanent 'record label', as a simple software update can wipe them out.

Culturally, the vast majority of the world has already accepted that computers are here to stay. Yet we still live in a society of obsolescence. Not only hardware-wise, but software-wise as well. How many people are still using Windows 3.1? How about DOS? One might argue that advances in hardware quickly made these older platforms go the way of the dodo, but why should digital media platforms have to go the same way?

Sooner or later, we'll need to establish a permanent cultural digital record. One that can be given an absolute virtual value and can remain "Future Compatible" into the indefinite future. It shouldn't be that difficult to create. The actual codecs required would need to be extremely robust. You'd need to aim for the perfect range for the human audio and visual range, achieving a higher resolution than anything possible with analog recordings or current digital standards.

These codecs would also have to be extensible, allowing for 'upgrades' to the code as the hardware advances to new levels.

The business model that would back this format should be based around a sharing system like Shared Media Licensing's system, but with the new Cultural Record acting to give back to the society that's acting to give it it's indefinite and virtual value.

Patents, patents, patents

I'm going to take a friend's advice and begin processing patents on all the devices I've come up with over the last few years.

This covers everything from the next generation of LEDs (untested) to any home or industrial appliance that requires a heating or cooling solution. The cooling solution might need to reference another patent, but the heating solutions so far are out of left field.

I'll need advice on how to process these though. I've got the designs, but need help writing the patent applications themselves.

Anyone out there familiar with patent law?

Welcome to 1984

I have some new beefs.

http://www.physorg.com/news104501218.html
http://www.physorg.com/news103997338.html

Over a year and a half ago, I gave away a design for a new solar cell thought up by myself and a friend. We considered it an obvious advancement over the old design simply because it removed a series of successive layers in the cell design and replaced them with a prism and multiple solar cells tuned to different wavelengths to allow for better absorption.

We also suggested, in the same email, using carbon nanotubes to deal with an heat-induced electron over-excitation problem, and suspending the quantum dots used in the design in a solution to allow them to be printed directly onto a substrate. These suggestions would serve to increase the efficiency while decreasing the cost.

We made these suggestions in January 2006. I'd been in contact with Evident Technologies regarding the obvious flaws in their peltier element design and they'd fired back a white paper on their solar cells to inform me of the potential in their QD design. I don't believe they were at all expecting to recieve a new solar cell design back.

I've contacted the 'inventors' of our design, who claim this 'revolutionary breakthrough design paradigm' is their own creation. However, they won't share who thought up the idea or any other information.

I'm pissed. We thought we were being naive when we sent off the design. Surely there must be scientists with lists of degrees longer than my arms that have already been over these pathways and had the same thoughts, tested them and discounted them.

Apparently not.

And now they're going to sell these cells to the American Military to make them better and more efficient killing/policing machines.

Here's the text from every email I recieved and sent to Evident. I've bolded the specific suggestions that have since been implemented.

Andrew Abbass	Tue, Jan 3, 2006 at 10:41 PM
To: strouse@chem.ucsb.edu, fwise@ccmr.cornell.edu Bcc: company@nanocrystals.com, info@evidenttech.com, andrew.abbass@gmail.com
Hello Sirs, My name is Andrew Abbass and I'm... well, I'd like to say an amature physicist, but I'm pretty much an amature everything else as well. (Meaning I don't get paid.) However, I've got this idea regarding a design for a peltier device that i believe is a step forwards in the field, but I haven't found a receptive ear to explain it to yet. If you've time to spare to hear me out, I'd appreciate it. -Andrew Abbass

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Andrew Abbass	Thu, Jan 5, 2006 at 5:09 PM
To: strouse@chem.ucsb.edu, fwise@ccmr.cornell.edu, company@nanocrystals.com, info@evidenttech.com, andrew.abbass@gmail.com
Hello, I'd sent my original email a few days ago concerning a development in peltier designs, but i still have not recieved a response. My interest isn't in the composition of the devices, but the orientation. I believe I've found something that's been overlooked in the designs that has instant and immediate applications in everything from computer cooling to home heating. I'd like to speak further with a someone regarding this. I await your response. -Andrew Abbass Newdor.com Media Inc. [Quoted text hidden]

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Amib2@aol.com	Thu, Jan 5, 2006 at 7:47 PM
To: andrew.abbass@gmail.com
Send me a phone no where I could call you. I may not be able to help you a great deal but I least I would be appreciate your vision. Ramesh Bhargava

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Andrew Abbass	Thu, Jan 5, 2006 at 9:14 PM
To: "Amib2@aol.com"
Hey, It's not much of a vision yet. I just noticed something I'd never seen done with a peltier circuit. I'm in Labrador, which is a long distance call no matter where you are, but you can if you want. My number is (**********. I've got three basic scematics that I think might serve a different purpose than current peltier device configurations. -Andrew Abbass [Quoted text hidden]

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Christian Seemann	Fri, Jan 6, 2006 at 11:35 AM
To: Andrew Abbass
Dear Andrew, Thank you for your interest in our products. I apologize for not responding to you sooner. I would appreciate the ability to speak with you more about this application. Please contact me either by phone or email at your convenience. I look forward to future correspondence with you and to the development of an opportunity. Best regards, Christian Christian Seemann Nanomaterials Technical Inside Sales Representative Evident Technologies Inc. 216 River Street, Suite 200 Troy, NY 12180 USA T: 518-272-6266 x2214 F:518-273-6267 CONFIDENTIALITY NOTICE: This e-mail, including attachments, is for the sole use of the individual to whom it is addressed. This message is confidential and may contain information that is privileged, confidential and is exempt from disclosure under applicable law. Any unauthorized review, use, disclosure or distribution is prohibited. If you have received this e-mail in error, please notify the sender by reply e-mail and destroy this message and its attachments. [Quoted text hidden]

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Andrew Abbass	Sun, Jan 8, 2006 at 1:35 PM
To: Amib2@aol.com, cseemann@evidenttech.com, andrew.abbass@gmail.com
Hello Gents, Thank you for sparing the time to hear me out. I've been taking my time trying to come up with a way to describe this, but I'm not really sure of the language I'll use. So... I'll just go ahead and run with what I've got and see if any of it makes sense. I've been looking at peltier gates and their classical uses and wondering if the current generation of peltier devices have been designed with the wrong dimensions in mind. Currently, the devices are designed like a sandwich with a hotside and a cold side. I'm wondering about the applications of this gate when used in as a 2 dimensional lattice. I've attached a basic design that I hope will help get the idea across. I've also got in mind another version that's Y-shaped with one element transfering heat into two seperate elements to increase the surface area the heat can be spread over and radiated away from. (I call that one a 'flux capacitor', although the makers of Back to the Future may want to claim the rights to that one.) The version shown in the attached diagram I've dubbed an 'entropy wheel'. I haven't completed a test version yet, but if if works the way I think it will, a current in one direction should produce a net decrease in heat inside the central point of the diagram, while a current flowing in the other direction should produce a net increase in heat. If my theory holds out, then I believe I've successfully suspended the 2nd law of thermodynamics by vectorizing entropy in an organized construct. There should also be a net increase or decrease in entropy in the area surrounding the circuit depending on the direction of the current flow to preserve the 1st Law, but the energy is being dispersed over a larger surface area. -Andrew Abbass Thanks for your time. figure5.JPG 39K

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Andrew Abbass	Mon, Jan 9, 2006 at 6:28 PM
To: Amib2@aol.com, cseemann@evidenttech.com, andrew.abbass@gmail.com
I've got more information on these devices. And I've worked out a few theories on what might be possible with them. This is just a general overview. I've put a bit of thought into it... I'd just like some confirmation from other sources. -Andrew

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Andrew Abbass	Tue, Jan 10, 2006 at 12:39 PM
To: Amib2@aol.com, cseemann@evidenttech.com
Any thoughts? -Andrew Abbass

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Christian Seemann	Tue, Jan 10, 2006 at 6:43 PM
To: Andrew Abbass
Dear Andrew, This sounds very interesting; I'm assuming that you are interested in the possibility of incorporating our EviDots into your device and using them as semiconductor material. From what I have read I would recommend that you use either our CdSe or PbSe EviDots as both are known for their energy transfer abilities. I have attached a white paper on the use of these EviDots in Solar Cell Energy Conversion. I believe that you will find this paper to be informative and interesting. I look forward to you thoughts. Best regards, Christian -----Original Message----- From: Andrew Abbass [mailto:andrew.abbass@gmail.com] Sent: Sunday, January 08, 2006 11:36 AM To: Amib2@aol.com; Christian Seemann; andrew.abbass@gmail.com Subject: Re: Quantum Dot-based Peltier Devices [Quoted text hidden] WhitePaper Solar Convers v1.0 eMail.pdf 1499K

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Andrew Abbass	Wed, Jan 11, 2006 at 10:35 PM
To: Christian Seemann , andrew.abbass@gmail.com
Hey Christian, I've been conversing with a friend of mine over the information you sent me. We were very intrigued by your approaches towards improving the efficency of solar cells using your EviDots and the Gratzel cell. Your story reminds me of one written by Robert A. Heinlein called "Let There Be Light". I believe you can find it to read in his book "The Man Who Sold The Moon". The story concerns itself with the invention of a sunscreen solar panel and our suggestions may have some similarities. 1. Use a carbon nanotube lattice combined with a modfied peltier circuit to actively dampen your over-excitation problem. The nanotube lattice should be able to keep the phonon vibrations at a minimum, maintaining an optimum operating temperature. 2. Rather than stacking the different elements of your Gratzel cell, why not use a prism to break the light into individual spectrums so each nanocrystal layer is absorbing it's own frequency directly? The characters in the aforementioned story used a similar technique to obtain their efficency levels. I believe it may offer you a similar result. I look forwards to your response. -Andrew Abbass

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Andrew Abbass	Wed, Jan 18, 2006 at 3:48 PM
To: Christian Seemann , andrew.abbass@gmail.com, "Amib2@aol.com"
Hello, It's been a while since I've heard a response from either of you gentlemen. I've pondering the general applications of p-n semiconductor junctions and have come to a number of conclusions, but am unable to justify my results without further labratory testing. One conclusion is that thermal diodes will never be able to attain a much higher efficency rating that currently available. It's like trying to make water flow up a waterfall. I do have another thought on their uses, as well as applications for even the low efficency levels, but would require an investor to develop the technology required to manufacture the thermal lattice i've got in mind. Christian, your solar cells still interest me, and I'm wondering if my thoughts on quartz diffraction for your gratzel cell were of any use. My main thoughts seem to concern the orientation of each p-n junction in relation to the wavelengths they are attempting to absorb. It seems to me that if a peltier junction would operate more efficently in 2 dimensions as a heat spreader than it currently does in traditional peltier devices, maybe there's an efficency issue to be found in solar cells for the same reason. -Andrew Abbass

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Frank Wise	Sat, Jan 21, 2006 at 8:46 PM
To: Andrew Abbass
I know almost nothing about the details of Peltier coolers, but I do know the main properties of QDs. If you want to run your thought by me or ask some questions I will try to help but I don't want to mismanage your expectations. ---------------------------------------------------------------- Frank Wise Department of Applied Physics 212 Clark Hall Cornell University Ithaca, NY 14853 T: (607) 255-1184 F: (607) 255-7658 fwise@ccmr.cornell.edu www.aep.cornell.edu/FFR/Faculty/Wise.html ---------------------------------------------------------------- [Quoted text hidden]

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Andrew Abbass	Mon, Jan 23, 2006 at 4:01 PM
To: Frank Wise
Hey Frank, I've got a question for you. When manufacturing a device using your QDs, can you suspend it in a solution to print the dots onto a substrate as if you were printing with ink? Because if you can, I think I've got a manufacturing process as well as circuit designs for you that will cut your solar cells production costs down, increase their efficency, as well as give you a whole new type of solid state heat engine for spot cooling of CPUs... I've even got a few ideas for LEDs, thermal diodes, the new e-ink devices, etc... Anyways, I'm looking forwards to a response. -Andrew Abbass

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Andrew Abbass	Thu, Jan 26, 2006 at 12:34 PM
To: Frank Wise , strouse@chem.ucsb.edu, company@nanocrystals.com, info@evidenttech.com
Hello, I'm attempting to contact someone regarding some new applications for your nanocrystals in the areas of heat transfer gates, solar cells and cheaper manufacturing processes. I've been trying for months now and have yet to make a solid connection. If someone out there would care to respond, I've been working on a unified field theory based around the actions of PN junctions on the quantum level. I think I've got it. -Andrew Abbass

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Frank Wise	Thu, Jan 26, 2006 at 9:43 PM
To: Andrew Abbass
We do not make any real devices. QDs are synthesized in solution, typically organic solvents. We can redisperse them in other solvents, and we can deposit them as films. Dots probably could be deposited or sprayed in a pattern. I don't know if anyone has done it nor the degree of control one would have. [Quoted text hidden]

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Andrew Abbass	Fri, Jan 27, 2006 at 2:47 AM
To: Frank Wise
Well, modern computer printers and produce a pretty fine droplet control. As long as you could maintain a fairly decent regularity you could deposit the dots in a 2 dimensional diode formation on a film? If it's already been printed with the necessary copper wiring you should be able to print quantum dot circuitry using two or more seperate tanks of QDs? Then you could seal the whole thing in one layer of laminate. Just a thought. I'm interested in testing a few designs for solar cells and heat transfer devices using a new 2 dimensional pn-junction lattice instead of the traditional 3 dimensional designs. -Andrew Abbass [Quoted text hidden]

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Andrew Abbass	Sat, Jan 28, 2006 at 3:32 AM
To: Frank Wise
Hello Frank, I did some looking, and there should be a way to provide for a relatively cheap conductive ink to use with the QDs in the printing process. I on the topic of QDs though... do you have anyone on your staff that studies quantum mechanics? I've got some material I'd like to run by them if possible. -Andrew Abbass [Quoted text hidden]

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Frank Wise	Wed, Feb 15, 2006 at 11:44 AM
To: Andrew Abbass
Yes, one of the benefits of colloidal synthesis is processability. I don't recall if we discussed it, but there are people working on potential applications of nanocrystals based on thermoelectric properties. [Quoted text hidden]

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Andrew Abbass	Wed, Feb 15, 2006 at 5:03 PM
To: Frank Wise
Well, I've been putting some thought into your QD products and their current applications. I think your biggest stumbling block is that you're still working with a passive layered design which is expensive to manufacture and doesn't provide for much in the way of efficency. I believe you have to change your stance towards designing a 2 dimensional light processing engine instead. This will mean that your energy collection process will be occuring at 90 degrees to your absorbtion process. This has already been shown to have a beneficial effect on solar cells. http://www.physorg.com/news4455.html This company has already make attempts using a nanospike technique, but I believe their just working on a middle ground step between the current layered design and a much more efficent 2 dimensional design. Think of it more like a light transistor and you're getting closer to what i'm thinking about. There's also a heat engine I've got in mind using a 2 dimensional version of a peltier gate. I'll go into more detail on that one with my next email. -Andrew Abbass

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Andrew Abbass	Tue, Apr 25, 2006 at 8:24 PM
To: Christian Seemann
Hey Christian, I found something on the net that I think would apply to our earlier discussions about using your quantum dots in gratzel cells. Using this holographic technique, you would be able to focus certain bands of light on certain portions of the gratzel cell, maximizing your absorbtion ratios. If you printed your gratzel cell as a single-dimensional superlattice in a two dimension space similar to the techniques used to print processors, you'd have a flat, easy to manufacture solar cell that you could print onto a substrate using your dots. Also, I don't know if you know this yet, but my hometown of Goose Bay, Labrador just became the world's largest supplier of high grade titanium oxide for use in these cells. I'd like to speak with you further. Can I call? -Andrew Abbass

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Andrew Abbass	Thu, Jul 26, 2007 at 2:24 AM
To: Christian Seemann
Hey Christian... I see evident is making use of our suggestions. http://www.physorg.com/news104501218.html http://www.physorg.com/news103997338.html What took you so long? -Andrew

Damn greedy American Science Community, sucking on the teat of the American Military.

Thankfully, I saved the high output LED designs. I'd rather they didn't end up in the US Military's hands. Between that and the heat management system I've got in mind, these two components a key ingredients to producing efficient miniaturized solid state laser systems.

Maybe I'll give it to the Chinese just to be a prick.

The Zune is 100% Broken

The Zune Scene and Slashdot are reporting that the Zune Marketplace DRM is now broken and 100% removable.

There was a real precedent set with the Weedshare incident. Two 'security upgrades', supposedly to protect the Zune Marketplace, were the official reason that SML closed it's doors. The fact that this can occur should shake the faith any might have in a digital media marketlace. Should the marketplace gain acceptance, simple software updates could trigger the next Great Depression. There has to be a mandated responsibility to the public.

Now that this protection has been broken as well, can we break through to daylight and try to examine this subject above the table and in full public view.